The Hepatobiliary Regenerative Medicine group focuses broadly on regenerative medicine strategies for the treatment of cholangiopathies, a diverse group of diseases targeting the biliary tree.

Aims

• Advance cell culture techniques for patient-derived biliary epithelial cells (BECs)
• Tune biomaterial properties for improved growth and function of BECs
• Fabricate bile duct-like structures in vitro
• Investigate BEC–biomaterial interactions and BEC functions in vitro
• Investigate the safety and efficacy of lab-generated bile duct-like structures in vivo

Focus

• Establishment of patient-derived BEC cultures
• Development of implantable bioartificial bile ducts
• Development of translational pathways for combined ATMPs in this area

Expertise and resources

• Primary adult and progenitor cell isolation/purification, culture, and functional characterization
• Biomaterial processing
• Histology and cell imaging techniques
• Functional and mechanistic studies
• Molecular biology

Team