The addition of simvastatin portal venous infusion to cold storage solution of explanted whole liver grafts for facing ischemia/reperfusion injury in an area with low rate of deceased donation

Abstract: The aim of the project was to test the possible clinical efficacy of administering Simvastatin intragastrically three hours before cross-clamping the whole liver from the deceased donor. The single-center, prospective and randomized double-blind study involved the enrollment of 106 patients and the comparison against the standard procedure on a sample treated only with placebo. This new administration of simvastatin could reduce donor liver damage and reduce the length of hospital stay as well as the rate of complications.