Funding Agency/Programme: Regione Siciliana – PO FESR 2014/2020 – Obiettivo Tematico 1 Ricerca, Sviluppo Tecnologico e Innovazione, Obiettivo specifico 1.1 – Incremento dell’attività di innovazione delle imprese, Azione 1.1.5 – Sostegno all’avanzamento tecnologico delle imprese attraverso il finanziamento di linee pilota e azioni di validazione precoce dei prodotti e di dimostrazione su larga scala.
Partnership: Casa di Cura Candela Spa (Coordinator); Fondazione Ri.MED; Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione S.r.l. – IRCCS ISMETT; OLOMEDIA SRL, S.R.L.; EXOSOMICS SIENA SPA.
Abstract: PROMETEO’s main objective is to develop cell products based on stem cells isolated from placenta for clinical applications. Specifically, cell therapies for acute and chronic liver diseases and for the reactivation of the endometrium will be developed through in vitro and in vivo studies. The therapeutic effects of cells and derivatives will be tested on in vivo models of acute and chronic liver damage and on in vitro models for endometrial reactivation. This process will be optimized according to protocols based on the principles of Good Manufacturing Practices (GMP), in order to develop cell therapies. Analytical methods will also be developed to evaluate any contamination in the final product according to specific protocols for the quality control (QC) of the cells, considering: the phenotype, functional potential, microbiological safety and tumorigenicity. All parts of the production process will be defined, optimized and standardized.
Scientific products:
- Human Amnion-Derived Mesenchymal Stromal Cells in Cirrhotic Patients with Refractory Ascites: A Possible Anti-Inflammatory Therapy for Preventing Spontaneous Bacterial Peritonitis
- Extracellular Vesicle-Derived MicroRNAs of Human Wharton’s Jelly Mesenchymal Stromal Cells May Activate Endogenous VEGF-A to Promote Angiogenesis
- Human Amnion-Derived Mesenchymal Stromal/Stem Cells Pre-Conditioning Inhibits Inflammation and Apoptosis of Immune and Parenchymal Cells in an In Vitro Model of Liver Ischemia/Reperfusion
